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fludrocortisone will minimize the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.iloperidone improves amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Iloperidone is usually a time-dependent CYP3A inhibitor and will cause amplified plasma